Enhanced biofilm and extracellular matrix production by chronic carriage versus acute isolates of Salmonella Typhi

Salmonella Typhi is the primary causative agent of typhoid fever; an acute systemic infection that leads to chronic carriage in 3–5% individuals. Chronic carriers are asymptomatic, difficult treat and serve as reservoirs for outbreaks. Understanding factors contribute key development novel therapies effectively resolve fever. Herein, although we observed no distinct clustering isolates via phylogenetic analysis, demonstrated were phenotypically from isolates. formed significantly thicker biofilms with greater biomass correlated higher relative levels extracellular DNA (eDNA) DNABII proteins than by Importantly, include integration host factor (IHF) histone-like protein (HU) critical structural integrity bacterial biofilms. In this study, biofilm a isolate vitro , was susceptible disruption specific antibody against proteins, successful first step therapeutic carriage.